Additionally, all generation II cases had TDP-43 inclusions in the amygdala and hippocampus, consistent with limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) stage 1 or 2 out of 3 [53] (Fig. 2d); TDP-43 inclusions were not seen in case I-2 (SORL1 variant negative). The gene discussed is SORL1; the disease is Encephalopathy.