NR1H4 and atherosclerosis: A study of sterol sulfate significantly improved atherosclerotic in high-fat-diet-fed Apo E2/2 mice showed changes in BA profiles in the liver, gallbladder, serum, and stool, and increased FXR expression in the liver, suggesting that FXR was one of the pathways through which BAs were involved in sterol sulfate in attenuating atherosclerosis (Ding et al. 2021).