The applications of the synthetic dsRNA targeting some important genes in the fungus, including cytochrome P450 lanosterol C-14α-demethylases (CYP) (Koch et al. 2016), Argonaute (AGO) RNase protein and DICER (Werner et al. 2020) and Tri6 (Hao et al. 2021), may reduce the fungal infection and improve the FHB resistance in wheat and barley. The gene discussed is DICER1; the disease is fungal infectious disease.