The chromosomal imbalances observed in clones and subclones have been previously described in sporadic parathyroid adenomas, i.e., copy number neutral LOH of MEN1 [10]; 1q and 15q loss [40]; partial loss of chromosome 9, 3q, 16q, and 17p gains [41]; as well as abnormal ploidy [42]. The gene discussed is MEN1; the disease is parathyroid gland adenoma.