WFDC2 and digestive system neoplasm: Interestingly, in patients with gastrointestinal tumors, it has been found that the expression of genes, such as TLRs [54, 55], WFDC2, TTLL12, THRA, and EPHB3 [56], which can trigger an immune response and release of pro-inflammatory factors [57] and thus accelerate tumor cell invasion, is disturbed.