The result indicated that the resistance of the GC cell line to L-OHP was also associated with the over-expression of apoptosis-associated proteins (e.g., Bcl-2 and Survivin) and classic resistance proteins (e.g., P-gp) and HD may be involved in the MDR of GC cells by inhibiting the expressions of MDR1/P-gp, Survivin, and Bcl-2. Here, PGP is linked to gastric cancer.