APOE and atherosclerosis: In an additional study in streptozotocin-induced apolipoprotein E deficient (Apoe-/-) mice, both 1,25(OH)2D3 and RXR agonist (bexarotene) reduced the expression of nuclear factor-kappa B (NF-κB) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, as well as the progression of atherosclerosis and indexes of oxidative stress and inflammation (MDA, IL-6), while increased the expression and levels of SOD [66].