A recent study has reported that altered expression of VDR-target genes in the aortic adventitia, like overexpression of growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) and nuclear receptor corepressor 1 (NCOR1), and lower expression of paraoxonases 2 (PON2), is connected with the greater risk of rheumatoid arthritis in coronary artery disease patients [36]. The gene discussed is PON2; the disease is coronary artery disorder.