Recent studies have highlighted the critical roles that RNA‐binding proteins (RBPs) can fulfill in modulating organogenesis, maturation, function, and cancer, alleviating endoplasmic reticulum stress by binding to RNAs and regulating their processing, stability, localization, modification, or translation.[46] In the current study, MIR503HG, an intergenic lncRNA, repressed CDH1 and HES1 transcription by binding to the RBP, and CtBP1, and adversely affecting pancreatic lineage specification. The gene discussed is CTBP1; the disease is cancer.