To further examine whether Hif2α activation can effectively alleviate hepcidin‐activated anemia, we crossed Tmprss6−/− mice with intestine‐specific Hif2α overexpression mice (Hif2αLSL/+) to generate Tmprss6−/−; Hif2αLSL/+ mice. This evidence concerns the gene EPAS1 and anemia.