Recent studies have highlighted Hif2α as a critical adaptive transcription factor to regulate intestinal iron absorption, which is highly upregulated in response to increased systemic iron demand.[20, 21, 22] Additionally, hepcidin inhibition leads to Hif2α activation, facilitating an appropriate iron absorptive response.[23] However, it remains unclear whether Hif2α activation can effectively alleviate hepcidin‐activated anemias. This evidence concerns the gene HAMP and anemia.