To further examine whether Hif2α activation can effectively alleviate hepcidin‐activated anemia, we crossed Tmprss6−/− mice with intestine‐specific Hif2α overexpression mice (Hif2αLSL/+) to generate Tmprss6−/−; Hif2αLSL/+ mice. The gene discussed is HAMP; the disease is anemia.