EPAS1 and anemia (phenotype): In this article, it is demonstrated that targeting the duodenal Hif2α‐Fpn axis as a novel strategy to improve refractory hepcidin‐activated anemias, including iron‐refractory iron‐deficiency anemia (IRIDA), inflammatory anemia and chemotherapy‐induced anemia, in mice, which provides compelling evidence for further clinical translation.