In the absenceof minocycline, the rate and extent of cytotoxicity displayed by MinoCARwere comparable to the monolithic EGFR CAR, while increasing concentrationsof minocycline induced a dose-dependent decrease in SKOV3 target cellkilling (Figure 4D).Next, we sought to investigate the ability of MinoCAR T cells to recoveractivity following inhibition with minocycline or, conversely, theability of the drug to inhibit MinoCAR T cells following their activationthrough exposure to tumor. Here, EGFR is linked to neoplasm.