This promotes the production of antibodies against thyroid-specific proteins (e.g., TPOAb, TGAb, TRAb), thyroid damage, and further development of hypothyroidism.1,2,6 In patients with HT, selenium supplementation can reduce TPOAb and TSH concentrations through several mechanisms, which can be related to the antioxidative and anti-inflammatory role of selenoproteins. This evidence concerns the gene SELENOS and hypothyroidism.