Subtype CS3 is significant associated with mismatch repair (MSI) (p < 0.001) and shows a much higher CpG island methylator phenotype (CIMP) (p < 0.001) as well as BRAF-mutant (p < 0.001), indicating that it demarcates the well-characterized MSI/CIMP + subset of CRC (Fig. 4C). The gene discussed is BRAF; the disease is colorectal carcinoma.