In the process of IDD, there are not only an obvious imbalance between the anabolism and catabolism of ECM [11] but also producing a large number of inflammatory factors such as TNF-α and IL-1β which promote the reduction of matrix by directly inhibiting the expression of matrix genes or by increasing the expression of collagen and aggregator lyase [29]. The gene discussed is TNF; the disease is intervertebral disk degenerative disorder.