In our study, we found that ALDH1A1 expression was low in children with SJIA compared to healthy children and that ALDH1A1 was positively correlated with T cell CD4 memory resting status and negatively correlated with T cell CD4 memory activation, consistent with previous reports that ALDH1A1 has an immunosuppressive function. This evidence concerns the gene CD4 and systemic-onset juvenile idiopathic arthritis.