The results indicated that compared to C-MitoCtrl, C-MitoHF increased the number of TH-positive nerve fibers (Fig. 9A, B) and GAP43-positive sprouting nerves in the myocardium of HF mice (Fig. 9C, D), which were ameliorated by reducing endothelial cGAS in the SFO of HF mice (Fig. 9A–D). The gene discussed is CGAS; the disease is hydrops fetalis.