The results showed that C-Mito were mainly entered the ECs (CD31 labeled) of the SFO in HF mice (Fig. 2C, D), instead of neurons (NeuN labeled), astroglia (GFAP labeled), and microglia (Iba-1 labeled) (Additional file 1: Fig. S2A–F). The gene discussed is PECAM1; the disease is hydrops fetalis.