Acute onset of gout is known to be related to gout crystals that stimulate the formation of NALP3 inflammasome by monocytes and promote the release of inflammatory factors, including Interleukin-2 (IL‐2) and tumor necrosis factor-α (TNF‐α), to act on joint synovium, which further causes inflammation expansion [20]. Here, NLRP3 is linked to gout.