RHOA and systemic lupus erythematosus: There has been growing evidence to indicate that RhoA mediates phosphorylation of STAT-3 and STAT-5 in several cell types via ROCK [29] and that targeted RhoA-ROCK inhibition modulates STAT-3 phosphorylation to shift toward a pathologic Th17/Treg imbalance in patients with lupus [28].