The RhoA/ROCK pathway has been implicated in lupus pathology in a prior study that showed that increased phosphorylation of the ezrin, radixin, and moesin (ERM) proteins interact with the macrophage migration inhibitory factor (MIF) co-receptor CD44 to promote the adhesion, migration and inflammatory response of T lymphocytes [40]. This evidence concerns the gene MIF and systemic lupus erythematosus.