PTX3 and neoplasm: Furthermore, beyond the previously identified potential of the PTX3 inhibitor WHC-001 for suppressing metastasis, invasion, stemness, and drug resistance in triple-negative breast cancer [29], our findings reveal a novel effect of WHC-001 on reversing immunosuppression by reducing the population of tumor-infiltrating M2 macrophages and increasing the population of tumor-infiltrating cytotoxic CD8+ T cells in colon tumors.