The knockout efficiency was examined by measuring the plasma Ptx3 level in both Ptx3fl/fl and Ptx3fl/fl;Ubc-Cre mice (Fig. 3D), and the results showed that under systemic Ptx3 deletion, MC38 tumor growth was attenuated (Fig. 3E), suggesting that PTX3 contributes to tumor progression. Here, PTX3 is linked to neoplasm.