In an orthotopic colon tumor model, blockade of PTX3 resulted in inhibited tumor growth (Fig. 4I and J), and this effect was also associated with a reduction in the number of tumor-infiltrating M2-like macrophages, while other myeloid populations, such as M1-like macrophages, PMN-MDSCs, and M-MDSCs, remained unaffected (Fig. 4K–N; Additional file 3: Fig. S4B). Here, PTX3 is linked to colonic neoplasm.