HSP90B1 and neoplasm: Furthermore, when stratifying tumor patients into stages I-II and III-IV based on disease progression, high expression levels of HSP90B1 were significantly increased in advanced stages for most cancers, including BLCA, KIRC, KIRP, and TGCT (all p < 0.05) (Fig. 1H, I, J and M), and even in early stages for certain cancer types like OV and THCA (Fig. 1K, L).