The analysis of 46 immunostimulatory genes in pan-cancer showed that HSP90B1 expression was positively correlated with CD40, CD270, PVR, MICB, ULBP1, TNFSF4, while exhibiting a negative correlation with CD48 and CD40LG in most cancers (Fig. 2C). The gene discussed is HSP90B1; the disease is cancer.