Our findings indicated that HSP90B1 serves as a risk factor for patients with ACC, CHOL, BLCA, CESC, GBM, KICH, etc., while acting as a protective factor for patients with LAML, OV, PCPG, THYM, UCEC (all p < 0.05) (Suppl. Here, HSP90B1 is linked to adrenal cortex carcinoma.