Through intratumoral injection, the functional chemokine CXCL10 is continuously expressed in the TME, attracting more CXCR3 + T cells there to kill tumor cells, and the recombinant adenovirus exhibits excellent ability to 'fire up' the TME and improve the anti-tumor efficiency of PD-1 antibodies [63]. This evidence concerns the gene CXCR3 and neoplasm.