Abbreviations: ADP, Adenosine diphosphate; CTGF, Connective tissue growth factor; DTC, Disseminated tumor cell; GDF, Growth differentiation factor; HIF, Hypoxia-inducible factor; HSC, Hepatic stellate cell; IGF-1, Insulin-like growth factor-1; IL, Interleukin; LP, Lipoprotein; MMP, Matrix metalloproteinaseo; OPG, Osteoprotegerin; RUNX, Runt-related transcription factor; TGF, Transforming growth factor; VEGF, Vascular endothelial growth factor. Here, CCN2 is linked to neoplasm.