Moreover, tumor cell elimination can be further facilitated by Kupffer cells and liver sinusoidal endothelial cells through the secretion of tumor necrosis factor (TNF), nitric oxide (NO), and reactive oxygen species (ROS), or via cell apoptosis mediated by the perforin-granzyme pathway or Fas-FasL pathway initiated by liver natural killer cells [72, 73]. Here, TNF is linked to neoplasm.