CD274 and metastatic neoplasm: Firstly, univariate Cox regression analysis indicated that baseline ECOG score, metastatic disease status, immunogram subtype, PD-L1 Expression (IC levels), immune phenotype, immune checkpoint expression, MHC class I antigen presenting machinery expression (APM), WNT signaling level, Lund molecular subtype, TNB levels and TMB levels were significantly associated with OS of ICI therapy (Additional file 7: Fig. S6A).