AKT1 and osteoarthritis: Furthermore, 3′-SL suppresses oxidative stress and inflammation by blocking the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3‐kinase/protein kinase B (PI3K/Akt) pathway/Nuclear factor kappa B (NF-κB) signaling pathways in IL-1β-treated SW135324; oral administration of 3′-SL suppresses cartilage destruction in the destabilization of the medial meniscus-induced osteoarthritis model25.