SAMM50 and neoplasm: Ingenuity pathway analysis revealed that ‘Natural Killer Cell Signalling’ and ‘Crosstalk between Dendritic Cells’ were uniquely enriched in Tumour Regression Grade (TRG) three resections compared to TRG 1, a finding supported by differential NK cell MCP-counter estimates and natural killer cell marker NCR1 expression between TRG1 and TRG3 tumour resection [24].