EGF signaling was characterized by enriched ligand-receptor pairing of heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) and amphiregulin (AREG) expressed by monocytes of DNMT3A CHIP-carriers with the receptors EGFR, ERRB2 or ERRB4 in cardiac cell types in healthy and heart failure conditions (Fig. 6d). The gene discussed is HBEGF; the disease is heart failure.