Compared with the crude regression analysis, the association did not change markedly after adjusting for age, sex, T2DM, hypertension, systolic pressure, diastolic pressure, past PCI or CABG, NYHA classification, ALT, LDL-C, CKMB and pro-BNP in the multivariate regression analysis (Table 4). This evidence concerns the gene NPPB and hypertensive disorder.