Serum S6 reacted to a core sequence “SWTAADT” shared by most of the HLA B and some C alleles and HLA-F and was completely negative with the three peptides in A locus (A1-A3) confirming the negative reactivity with proteins isolated from the T2DM and LCL3023 transfectants seen previously (Fig. 4f). The gene discussed is HLA-F; the disease is type 2 diabetes mellitus.