DNAJC6 and Parkinson disease: The predominant parkinsonian movement disorder phenotype and abnormal DaTScanTM imaging in patients with DNAJC6 mutations implicate striatonigral pathology; we have thus developed a patient-derived dopaminergic neuronal cell model to study the molecular pathophysiology underlying DNAJC6 parkinsonism, identifying key defects in synaptic vesicle recycling and neurodevelopment.