However, GAG-deficiency sharply decreased the infection of HPV in CHO745 cells (Fig. 1, B and C), and the reduction of sulfated glycans by chlorate sodium or siRNAs of NDST1 and NDST2 significantly inhibited the infection of HPV in HeLa cells (Fig. S8, D and E), verifying the critical role of HSPG in the primary adsorption process of HPV. The gene discussed is NDST1; the disease is infection.