Furthermore, the synaptic vesicle Synapsin 1 (Figures 2A–2C), gephyrin (inhibitory synapses) (Figures 2D–2F), and the calcium/calmodulin-dependent protein kinase II (CAMKIIa) (glutamatergic neurons) (Figures S1B–S1D) puncta were also increased in FUS-ALS. Here, GPHN is linked to amyotrophic lateral sclerosis.