Although mregDCs show similarities with tumor-induced CD1c+CD14+ cells, such as high expression of immunoregulatory markers, mregDCs are detected across all mature DC subsets (cDC1s, cDC2s, DC3s), thereby representing a tumor-induced cell state, while CD1c+CD14+ cells are cDC2 specific and present in both immature and mature states.36 This evidence concerns the gene CD1C and neoplasm.