CD8A and acral lentiginous melanoma: It is also interesting to note that all three scRNA-seq studies on acral melanoma tumours showed considerable lymphocyte heterogeneity, with presence of diverse B and T cell functional states,65 although when compared to cutaneous melanoma, acral melanoma tumours had less immune cell infiltration64 and were dominated by immunosuppressive T regulatory cells and exhausted CD8 T cells.63