CD8A and cutaneous melanoma: Diversity of T cells in these tumours was also reported, with the identification of different T cell subsets (e.g. CD4, CD8, T regulatory) and activation states,54 and these findings were corroborated in an expanded cohort of cutaneous melanoma patients55 and in scRNA-seq studies of isolated immune cells from cutaneous melanoma tumours.56, 57, 58 Importantly, these subsequent studies have provided in-depth characterisation of the diverse transcriptional states of CD8 and NK cells that reflect their phenotypic and functional differences.