PRAME and uveal melanoma: For example, scRNA-seq analysis of primary and metastatic uveal melanoma tumours identified four tumour cell clusters (BAP1 mutant vs BAP1 wildtype; PRAME negative vs PRAME positive) with 16 discrete transcriptional cell states, and multiple T cell subsets characterised by activation and exhaustion markers60; the latter was surprising given that uveal melanoma is typically considered to be immune cell-poor.