PLAT and intracranial hemorrhage: Although all these cases were successfully treated, the use of recombinant tissue plasminogen activator could have complications such as pulmonary, gastrointestinal and intracranial hemorrhage along with pulmonary emboli.8,10,21,22 To date, no specific recommendation exists about the management of anticoagulant therapy and thrombolysis in patients with IE, considering the low level of evidence available especially in neonatal population, and decisions should be made on an individual basis.14,15