CX3CR1 and neoplasm: Its deficiency is detrimental to various acute inflammatory responses and exacerbates inflammation.[15] Recently, it has also been found that CX3CR1 was a marker for T-cell differentiation, and CX3CR1 + CD8 + T cells exhibited strong cytotoxicity in antiviral immunity.[16] Studies also have found in breast, prostate, and pancreatic cancer, CX3CR1 is involved in tumor cells spreading and metastasis.[17] However, the immune functional and prognostic value of CX3CR1 in epithelial ovarian cancer has not been clarified.