CX3CR1 and neoplasm: CX3CR1 was a chemokine receptor mainly expressed on immune cell membranes, and combined with its unique ligand CX3CL1, mediates tissue chemotaxis and adhesion of immune cells.[29] Studies found in tumor, CX3CR1 expressed by tumor associated macrophage and tumor cells.[30] However, the real role of CX3CR1 in the epithelial ovarian cancer was still controversial.