In the French and British populations dominated by HPV16 European variants, there was no significant association of HPV16 variants with persistent HPV infection and cervical disease progression.[35,36] Another study found no correlation of HPV16 E6 and E7 gene mutations with the expression level of tumor suppressor p53 in Indonesian women.[24] Moreover, EP[a], the most common variant identified in a clinical study of 10,000 women in Costa Rica, also showed no association with CxCa.[25] In this study, T178G/A, T350G, A131C, and T241G were the most frequent mutations of HPV16 E6 gene. This evidence concerns the gene TP53 and cervicitis.