EML4 and metastatic malignant neoplasm in the lymph nodes: Previous study has reported that the expression of LOC399815 is significantly related to the clinical characteristics of patients with lung squamous cell carcinoma, including factors such as gender and lymph node metastasis.[11] This fusion mode comprised exon 1–5 of lncRNA LOC399815 and exon 20–29 of ALK, the entire ALK kinase domain is preserved, like the classical EML4-ALK (E4: A20) fusion structure.