It is vital to remember that corticosteroids, intravenous immunoglobulin (IVIG), splenectomy, and anti-RhD immunoglobulin have all been used in the past to treat ITP.[28] The fact that these treatments have not been thoroughly investigated in randomized clinical trials must be emphasized, as these older therapies have variable efficacy and well-described side effects, with minimal benefits to many patients. This evidence concerns the gene RHD and autoimmune thrombocytopenic purpura.