The study further aims to evaluate the various diagnostic modalities available for HF, including advanced imaging techniques, biomarkers, and comprehensive clinical assessments, emphasizing the importance of accurate and timely diagnosis for effective management.[7–9] Pharmacological interventions, a cornerstone of HF management, will be critically examined, encompassing traditional medications such as diuretics, ACE inhibitors, and newer drug classes transforming the treatment landscape.[10,11]. The gene discussed is ACE; the disease is hydrops fetalis.