The main clinical manifestations are recurrent fever, analgesia, anhidrosis, mental retardation, and self-injurious behavior, which was first reported by Swanson in 1963.[3,4] The pathogenic gene NTRK1 is located on the long arm of chromosome 1 (1q21-q22), with a total length of approximately 23 kb and consists of 17 exons, encoding neurotrophic tyrosine kinase receptor type 1 (NTKR1), namely tropomyosin-related kinase A (TRKA). The gene discussed is NTRK1; the disease is anhidrosis.