Annamalai et al[106] treated OS MG-63 cells with a phytochemical called β-caryophyllene and found that β-caryophyllene regulated the JAK1/STAT3 signaling pathway in MG-63 cells through the mitochondrial apoptosis pathway induced by DNA fragmentation, and further promoted tumor cell apoptosis and inflammation. Here, STAT3 is linked to neoplasm.