VEGFA and neoplasm: Among them, PTEN inhibits the growth of OS cells by regulating tumor cell proliferation, Bax by regulating apoptosis, LC3 and mTOR by regulating autophagy in tumor cells, while VEGF by regulating angiogenesis.[17] Previous studies have also found[18–21] that PI3K, Akt, PTEN, Bax, LC3, VEGF, mTOR, GSK-3, p-PI3K, p-Akt, and p-mTOR proteins are all relevant targets on the PI3K/Akt signaling pathway, while affecting the progression of OS with the help of the conduction of this pathway.