Similarly, Farnood et al, Zahedipour et al[92,111] applied curcumin to OS cells, and found that this compound could also downregulate Notch-1, Hes-1, Hey-1, and Hey-2 mRNA expression levels, inhibit cyclin D1, MMP-2, and MMP-9 protein expression levels, and regulate tumor cell growth, inflammatory expression, and apoptotic progression by inhibiting the Notch signaling pathway, so as to have the properties of anti-inflammatory, anti-oxidant, and anti-cancer. This evidence concerns the gene NOTCH1 and neoplasm.