Wang et al and Vundavilli et al[108,109] all found that tanshinone I up-regulated the ratio of Bax to Bcl-2 protein by inhibiting the JAK/STAT3 signaling pathway, and inhibited the expression of matrix metalloenzymes (including MMP-2, MMP-9) protein associated with tumor invasion and migration, thereby delaying the growth and metastasis of OS. Here, MMP2 is linked to neoplasm.