Nrf2, as a transcription factor, belongs to the Cap “n” collar subfamily of basic leucine zipper proteins, and promotes the survival of normal cells, cancer cells, cancer stem cells (CSC) by regulating redox homeostasis, cellular metabolism and the expression of xenobiotic detoxifying enzymes.[77] The Hippo/YAP signaling pathway plays an important role in organ development, cell proliferation, homeostasis and regeneration. The gene discussed is CREB3; the disease is cancer.