Ferroptosis is a programmed cell death form dependent on the concentration of iron ion and closely related to excessive lipid peroxides, which can not only target and regulate key molecules (such as GPX4 or System Xc-) to induce iron death in tumor cells, but also target and regulate the oxidative level of iron ion (FINO2) or the overload od intracellular iron ion (FeCI2) to induce ferroptosis in tumor cells. The gene discussed is GPX4; the disease is neoplasm.