A 5-year cohort study in a Chinese adult population revealed that the triglyceride (TG)/HDL-c ratio was positively associated with the incidence of diabetes in prediabetic patients, which was supported by the results of a 10-year follow-up study in Iran.[36,37] However, the aspartate aminotransferase (AST)/ALT ratio was negatively associated with the risk of diabetes in prediabetic patients,[38,39] suggesting that regular monitoring of liver function levels in prediabetic patients could help prevent or slow the progression of diabetes. The gene discussed is GPT; the disease is diabetes mellitus.