In addition, it was found that prediabetes has an independent role in the development of glomerular hyperfiltration and albumin,[31,32] while prediabetes and the risk of renal dysfunction showed a positive correlation.[33,34] Both fasting glucose and HbA1C could be used as predictors of reduced renal function,[33,35] and postprandial glucose had a higher predictive value for renal dysfunction.[34] Moreover, high-density lipoprotein cholesterol (HDL-c) and alanine aminotransferase (ALT) are also strongly associated with prediabetes. The gene discussed is ALB; the disease is prediabetes syndrome.