The study involved 1,162 patients, with the following characteristics: mean age, 53.6 ±14.5 years; proportion of female, 608 (52.4%); BMI, 22.0 ±3.3 kg/m2; cardiovascular disease, 289 (24.9%); diabetes, 264 (27.1%); connective tissue diseases, 34 (2.9%); tuberculosis history, 89 (7.6%); serum albumin, 35.0 ±4.9g/L; median RRF, 3.1 (1.8, 5.1) ml/min/1.73m2; total Kt/Vure, 1.76 ±0.61. This evidence concerns the gene ALB and connective tissue disorder.