TP53 and breast cancer: Other important gene-trait associations included TP53 mutations associated with B cell receptor (BCR) function in breast cancer (BRCA), PBRM1 mutations associated with neutrophil in kidney renal clear cell carcinoma, IDH1 mutations associated with lower lymph vessel signature in Brain Lower Grade Glioma (LGG) and BRAF mutation associated with NK cell and macrophages in Thyroid Carcinoma (THCA).