FAM3C and cancer: To better characterize cell-cell communication changes due to NRF2 pathway activation, we plotted out the expression profile of top 50 ligands positively correlated with NRF2 signature in cancer cells (Fig 5E), which indicated that three genes (CD274, PVR, FAM3C) are ligands for well-known inhibitory immune check point receptors PDCD1 and TIGIT on T cells.