KEAP1 and cancer: NRF2 gene signature score calculated from cancer cell pseudo-bulk expression separates KEAP1 mutated samples from non-mutated samples in Maynard et al study, suggesting that NRF2 gene signature is a good indicator of KEAP1 mutation status (Fig 4E, fisher exact test p value < 0.05) and we could use NRF2 gene signature to infer the molecular impact from KEAP1 mutations in other scRNA-seq studies for which no mutation information is available [13].