For type 2 diabetes, there seems to be a consistent change in results (for both plain and total water) when adding adjustment for energy intake, energy intake misreporting, BMI, hypertension, lipid lowering medication, apolipoprotein A, apolipoprotein B. This could suggest such factors are affecting the relationship; for example, higher BMI is a risk for type 2 diabetes, and by proxy of higher energy intake and fluid needs, more water is consumed. The gene discussed is APOB; the disease is Hypertension.