The IPA of the DEGs that were exclusively expressed in periodontitis in diabetic patients revealed a significant upregulation of the Phagosome Formation pathway through the alterations in the expression of genes required for actin cytoskeleton rearrangements, membrane ruffle formation, and phagosome closure (e.g., complement, complement receptor (CR), ITGs, GPCRs, scavenger receptor, toll-like receptor, LPS binding protein, Fc receptor, C-type lectin domain family 4 member E, chemokine receptor, and PL) [23]. This evidence concerns the gene CLEC4E and periodontitis.