Furthermore, T2DM-related periodontitis was associated with the dysregulation of functional pathways, including the activation of Phagosome Formation, Cardiac β-adrenergic, tRNA Splicing, and PI3K/AKT pathways and inhibition of Cholesterol Biosynthesis, Adrenomedullin, and Inositol Phosphate Compounds pathways. The gene discussed is AKT1; the disease is type 2 diabetes mellitus.