These results suggest that it might be interesting to propose familial studies in patients with CYP1B1 hypomorphic alleles to identify asymptomatic carriers of the variant for close ophthalmological follow-up.Besides, we also identified for the first time the variant c.83C>G (p.S28W) in the CYP1B1 gene in a patient with a moderate glaucoma and myopia. Here, CYP1B1 is linked to myopia.