GHR and Severe short stature: Since Laron’s first description of dwarfism in humans due to defects in the GHR (Eshet et al., 1984; Laron, 2004; Laron et al., 1966), an enormous amount of progress has been made to understand how GH and IGF-1, as well as their binding proteins, receptors, and signaling pathways, contribute to linear growth (David et al., 2011; Savage et al., 2011; Lanning and Carter-Su, 2006; Hwa et al., 2021).