KRT80 expression was shown to be substantially related with increased lymph node and distant metastasis, as well as a higher pathological stage of colorectal cancer.5,11 KRT80 expression was significantly associated with lower disease-free survival, and overall survival in colorectal cancer patients as an independent prognostic indicator.5 Sanada et al.13 found that KRT80 was a prognostic factor for the lung adenocarcinoma patients. The gene discussed is KRT80; the disease is colorectal cancer.