Among negatively correlated genes, a higher expression of CLDNI5 and IL2RG, and was seen in esophageal cancer than normal tissue (Supplementary Figure S3b, p < .05), but the converse was true for DGKD, CLDNI8, TMEM220-AS1, TMEM220, C3orf86, and SSR2 (Supplementary Figure S3b, p < .0.05). This evidence concerns the gene DGKD and esophageal cancer.