Reportedly, pyroptosis is a recently discovered form of inflammatory programmed necrosis characterized by Caspase-1 -mediated cell death and its signal proteins are also composed of Gasdermin D, IL-18 and IL-1β.22 Twist is found to promote EMT with E-cadherin overexpression and N-cadherin under-expression.23 Therefore, we believed that KRT80 knockdown promoted the pyroptosis, and suppressed EMT of esophageal cancer cells by increasing slug and snail. This evidence concerns the gene IL18 and esophageal cancer.