In agreement with the report in gastric cancer,10 a negative relationship between promoter methylation and the expression level of the KRT80 gene was found in esophageal cancer and KRT80 hypomethylation was observed in esophageal cancer, suggesting that KRT80 hypomethylation might be responsible for its up-regulation, which should be investigated in the future. The gene discussed is KRT80; the disease is gastric cancer.