KRT80-related genes were shown to be highly expressed in the cell cycle, DNA replication, immune system, protein, and RNA metabolism, signal transduction, and other cellular processes.5,6 CircPIP5K1A activated KRT80 to promote proliferation, invasion, migration, and EMT of gastric cancer cells,16 while TCONS_00049140 inactivated KRT80 and increased proliferation and melanin production of mouse melanocytes.17 Perone et al.18 demonstrated that SREBP1 drove Keratin-80-dependent cytoskeletal rearrangements and invasive behavior in endocrine-resistant ERα breast cancer. The gene discussed is SREBF1; the disease is breast cancer.