Furthermore, KRT80 knockdown was reported to inhibit proliferation, anti-apoptosis, anti-pyroptosis, migration, invasion, and epithelial- mesenchymal transition (EMT) in gastric cancer cells.10 Tong et al.14 found that depletion of KRT80 restrained proliferation, migration, invasion, and EMT of lung cancer cells by affecting the TGF-β/SMAD pathway. Here, TGFB1 is linked to lung cancer.