Lipid management is essential for preventing cardiovascular morbidity and mortality.1,2 Apolipoprotein B (apoB) is emerging as the predominant trait that accounts for the etiological associations of lipid traits with coronary artery disease (CAD).3 An association of low-density lipoprotein cholesterol (LDL-C) with CAD is widely accepted,4 and an association of triglycerides (TG) with CAD is also gaining acceptance.5,6 However, dose-response associations of these lipid traits with CAD and mortality remain unclear. The gene discussed is APOB; the disease is coronary artery disorder.