IGF2 and rhabdomyosarcoma: In rhabdomyosarcoma, PLAG1 was shown to upregulate insulin-like growth factor 2 (Igf2), a known target gene [1], alter alpha serine/threonine kinase (AKT) and mitogen-activated protein kinase (MAPK) pathways and positively regulate proliferation and survival of rhabdomyosarcoma cells [5].